Nephrogenesis (Journal - Experimental Nephrology , Vol 4, No 2) Book PDF, ePub eBook

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Book Descriptions:
Special Topic Issue: Vol. 4, No. 2 (1996) Experimental Nephrology This special issue explains how cell, molecular and genetic biology are enhancing our understanding of the mechanisms of normal nephrogenesis and are also showing how these processes go wrong in kidney malformations and polycystic diseases. A breakthrough in mammalian biology has been the ability to 'knock out' genes in mice. At the same time, the ability to genetically manipulate metanephric tissue in vitro and to clone metanephric lines permits an analysis of kidney lineage and growth at the level of single cells. These studies, which are covered in this issue, have suggested that a handful of genes are essential for the formation of a kidney in vivo, while other genes appear to modify the survival, prolif-eration, differentiation and morphogenesis of specific populations of cells. Although the idea of fetal renal therapy still appears a distant prospect, we can now at least conceive that the survival and differentiation of renal precursor cells can be modified by genetic or other means - such thoughts would have been pure conjecture only a decade ago.

Nephrogenesis (Journal - Experimental Nephrology , Vol 4, No 2)

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